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Psychedelic Neuroplasticity and the GL Phase Transition

Jean-Paul Niko

Zenodo (CERN European Organization for Nuclear Research) March 28, 2026 DOI: 10.5281/zenodo.19285123 (opens in new tab) via OpenAlex

Summary

AI-generated from the abstract

Psychedelic compounds induce a temporary phase transition in the neural identity condensate, increasing plasticity as alpha crosses zero and enabling reorganization of the condensate. This framework explains the therapeutic window and highlights the importance of set and setting in psychedelic therapy.

Study at a glance

Characteristics Theoretical or philosophical paper Peer reviewed
Topics Neuroplasticity
Keywords Transition genetics Phase matter Neuroscience Identity music
Key finding Proposes that psychedelic compounds induce a phase transition in the neural identity condensate, increasing plasticity and enabling reorganization, which accounts for the therapeutic window and the role of set and setting.

Abstract

We present a GL framework for psychedelic therapy showing that psychedelic compounds induce a temporary phase transition in the neural identity condensate — increasing plasticity (alpha crosses zero) and enabling condensate reorganization. This explains the therapeutic window and the importance of set and setting. Part of the RTSG companion paper series.

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