Unveiling the role of single versus repeated low-dose ketamine in attenuating doxorubicin-induced chemobrain and depression in rats: differential modulation of neuroinflammation, phosphorylated GLT-1, SERT, DAT, and BDNF/TrkB signaling.
Nehal G. Fahmy, Nada M. Kamel, Mahmoud M. Khattab, Radwa N. Muhammad
Neuropharmacology June 1, 2026 DOI: 10.1016/j.neuropharm.2026.111055 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal study Peer reviewed |
|---|---|
| Population | Rats |
| Intervention | Ketamine |
| Dose | low dose |
| Topics | Depression Esketamine Ketamine |
| Key points | A single low dose of ketamine attenuates doxorubicin-induced chemobrain and depression in rats by modulating neuroinflammation, phosphorylated GLT-1, SERT, DAT, and BDNF/TrkB signaling more effectively than repeated low doses. |
Abstract
Unveiling the role of single versus repeated low-dose ketamine in attenuating doxorubicin-induced chemobrain and depression in rats: differential modulation of neuroinflammation, phosphorylated GLT-1, SERT, DAT, and BDNF/TrkB signaling.