Intranasal 5-MeO-DMT Concomitant with SSRI for Treatment-Resistant Depression: A Proof-of-Concept Trial.
Mathieu Seynaeve, Fiona Dunbar, Chandni Hindocha, Anna O. Ermakova, Mimi Pierce, Robert R. Conley, Claire T. Roberts
CNS Drugs March 24, 2026 DOI: 10.1007/s40263-025-01250-z (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Proof-of-concept trial Peer reviewed |
|---|---|
| Population | People with treatment-resistant depression |
| Interventions | Intranasal 5-MeO-DMT SSRI |
| Topics | 5-MeO-DMT Depression DMT |
| Key findings | Intranasal 5-MeO-DMT combined with an SSRI was well tolerated and showed preliminary antidepressant effects in treatment-resistant depression. |
Abstract
Intranasal 5-MeO-DMT Concomitant with SSRI for Treatment-Resistant Depression: A Proof-of-Concept Trial.