Contribution of the Serotonin 5-HT2A Receptor to the Therapeutic Effect of Psilocin on Social Behavior Deficits in Mice Repeatedly Exposed to Social Defeat Stress.
Daisuke Ibi, Rika Takaba, Keisuke Yoshida, Ririna Kawase, Hiroko Kitagawa, Momoko Matsushita, Kana Ito, Shoya Uno, Fumiya Nishimura, Shinji Kitagaki, Masayuki Hiramatsu
Neuropsychopharmacol Rep September 1, 2026 DOI: 10.1002/npr2.70152 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study using a mouse model Peer reviewed |
|---|---|
| Population | Mice repeatedly exposed to social defeat stress |
| Intervention | Psilocin |
| Topics | Psilocybin Serotonin |
| Key findings | Psilocin reverses social behavior deficits in stressed mice through activation of the serotonin 5-HT2A receptor. |
Abstract
Contribution of the Serotonin 5-HT2A Receptor to the Therapeutic Effect of Psilocin on Social Behavior Deficits in Mice Repeatedly Exposed to Social Defeat Stress.