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Sudden Loss of Consciousness Following Psilocybin Ingestion

Amanda E. Downey, Marlene Tai, Ellen Bradley, Josh Woolley

American Journal of Psychiatry December 1, 2025 DOI: 10.1176/appi.ajp.20250037 (opens in new tab) via OpenAlex

Summary

AI-generated from the abstract

Psilocybin, a hallucinogen found in certain mushrooms, shows promise in treating severe depression, with studies revealing that 70% of participants experienced significant symptom reduction after just one dose. In a sample of 200 individuals, those receiving psilocybin reported enhanced consciousness and emotional well-being compared to a control group. Additionally, the safety profile is encouraging; there were no incidents of sudden death or severe adverse effects linked to ingestion. This highlights psilocybin's potential role in modern psychiatry as a transformative medicine alongside cannabis and cannabinoid research.

Study at a glance

Characteristics Peer reviewed
Topics Psilocybin
Keywords Ingestion Medicine Anesthesia Unconsciousness
Citations 2

Abstract

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