De novo sequencing and analysis of Lophophora williamsii transcriptome, and searching for putative genes involved in mescaline biosynthesis
Enrique Ibarra‐laclette, Flor Zamudio Hernández, Claudia Pérez-torres, Victor A. Albert, Enrique Ramı́rez-chávez, Jorge Molina‐torres, Araceli Fernández-cortés, Carlos Calderón‐vázquez, José Luís Olivares-Romero, Alfredo Herrera‐estrella, Luís Herrera‐estrella
BMC Genomics September 1, 2015 DOI: 10.1186/s12864-015-1821-9 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Transcriptome sequencing analysis Peer reviewed |
|---|---|
| Population | Lophophora williamsii |
| Topics | Mescaline |
| Keywords | Kegg Transcriptome Sequence assembly Genetics Pyrosequencing Genome Computational biology Botany |
| Citations | 26 |
| Key points | Candidate genes including tyrosine/DOPA decarboxylase, hydroxylases, and O-methyltransferases were identified as potentially involved in mescaline biosynthesis. |
Abstract
High throughput transcriptome sequencing (RNA-seq) analysis allowed us to efficiently identify candidate genes involved in mescaline biosynthetic pathway in L. williamsii; these included tyrosine/DOPA decarboxylase, hydroxylases, and O-methyltransferases. This study sets the theoretical foundation for bioassay design directed at confirming the participation of these genes in mescaline production.
Citations in the library
Cited by 9
- Dark Classics in Chemical Neuroscience: Mescaline ACS Chemical Neuroscience May 30, 2018
- Elucidation of the mescaline biosynthetic pathway in peyote (Lophophora williamsii). The Plant Journal November 1, 2023
- The biosynthetic pathway of the hallucinogen mescaline and its heterologous reconstruction Molecular Plant June 3, 2024
- An Overview on the Hallucinogenic Peyote and Its Alkaloid Mescaline: The Importance of Context, Ceremony and Culture Molecules December 5, 2023
- The Alkaloids from Lophophora diffusa and Other "False Peyotes". Journal of Natural Products August 27, 2021
and 4 more in the library
Cites 2
- Novel, Unifying Mechanism for Mescaline in The Central Nervous System: Electrochemistry, Catechol Redox Metabolite, Receptor, Cell Signaling and Structure Activity Relationships Oxidative Medicine and Cellular Longevity 2009
- Peyote identification on the basis of differences in morphology, mescaline content, and trnL/trnF sequence between Lophophora williamsii and L. diffusa Journal of Natural Medicines October 1, 2010