Antidepressive and anxiolytic effects of ayahuasca: a systematic literature review of animal and human studies
Rafael G. Dos Santos, Flávia de Lima Osório, José Alexandre S. Crippa, Jaime E. C. Hallak
Brazilian Journal of Psychiatry March 1, 2016 DOI: 10.1590/1516-4446-2015-1701 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Topics | Anxiety Ayahuasca |
| Keywords | Harmaline Anxiolytic Harmine Depression economics Hallucinogen Pharmacology |
| Citations | 158 |
| Key findings | Ayahuasca and its alkaloids warrant further investigation as potential treatments for anxiety and depression with fewer adverse effects. |
Abstract
Considering the need for new drugs that produce fewer adverse effects and are more effective in reducing anxiety and depression symptomatology, the described effects of ayahuasca and its alkaloids should be further investigated.
In the evidence
This study is part of the evidence base for a synthesis in the library. Here is how each one recorded it.
-
Ayahuasca and its alkaloids warrant further investigation as potential treatments for anxiety and depression with fewer adverse effects.
Synthesized
Comparable studies
Other narrative reviews on ayahuasca for anxiety, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Ayahuasca: Pharmacology, neuroscience and therapeutic potential | 2016 | Review | |
| Ayahuasca, an ancient substance with traditional and contemporary use in neuropsychiatry and neuroscience | 2019 | Review | |
| Hallucinogenic/psychedelic 5HT2A receptor agonists as rapid antidepressant therapeutics: Evidence and mechanisms of action | 2021 | Review | |
| Dimethyltryptamine: Endogenous Role and Therapeutic Potential Humans | 2019 | Review | |
| Psychedelics and Personality | 2018 | Review |