Yale Program for Psychedelic Science (YPPS) Manual for Psilocybin-OCD Session Monitors for Protocol HIC: 2000020355
Terence H. W. Ching, Stephen A. Kichuk, Giuliana DePalmer, Christopher Pittenger, Benjamin Kelmendi
October 5, 2022 preprint DOI: 10.31234/osf.io/85s9p (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Double-blind, placebo-controlled study |
|---|---|
| Population | Eligible participants with obsessive-compulsive disorder (OCD) |
| Intervention | Psilocybin |
| Dose | 0.25 mg/kg |
| Topics | Anxiety Psilocybin |
| Keywords | Dosing Obsessive compulsive Context archaeology Exposure therapy Psychotherapist Clinical psychology Pharmacology Hallucinogen |
| Citations | 5 |
| Key points | The study is testing the safety and efficacy of a single 0.25 mg/kg dose of psilocybin with non-directive support for OCD. |
Abstract
The Yale Program for Psychedelic Science (YPPS) is testing the safety and efficacy of psilocybin, administered in conjunction with non-directive psychological support, as a treatment for certain neurological and psychiatric conditions. The study, HIC: 200020355 (Neural correlates of the effects of psilocybin in obsessive-compulsive disorder: A double-blind, placebo-controlled study), will explore the safety and efficacy of a single 0.25 mg/kg dose of psilocybin, administered in a supportive clinical environment, to eligible participants with obsessive-compulsive disorder (OCD). Monitors meet with each participant before, during, and after the dosing session. Monitors do not provide any structured therapy, but rather help participants prepare for the experience of psilocybin dosing, ensure psychological safety during dosing, and provide participants with an unstructured context in which to process their experience during and after dosing at defined timepoints. In doing so, while no structured therapy is provided, the presence and accompaniment by monitors throughout all study sessions may be experienced as supportive or even therapeutic by participants. This manual provides background and details for Monitors on the activities that are required at three points – before, during, and after the dosing session.
Comparable studies
Other randomized controlled trials on psilocybin for anxiety, most cited first.