Acute, subacute and long-term subjective effects of psilocybin in healthy humans: a pooled analysis of experimental studies
Erich Studerus, Michael Kometer, Felix Hasler, Franz X. Vollenweider
Journal of Psychopharmacology September 20, 2010 DOI: 10.1177/0269881110382466 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Pooled analysis of double-blind placebo-controlled experimental studies Peer reviewed |
|---|---|
| Sample size | 110 |
| Population | Healthy human subjects |
| Intervention | Psilocybin |
| Dose | 45–315 µg/kg body weight |
| Topics | Anxiety Psilocybin |
| Keywords | Dysphoria Hallucinogen Adverse effect Context archaeology Mood Placebo Psychosis Clinical psychology Pharmacology |
| Citations | 529 |
| Key findings | Moderate doses of psilocybin in healthy, well-prepared subjects under careful monitoring produce an acceptable level of risk, with acute adverse reactions limited to high doses and manageable without medication. |
Abstract
Psilocybin and related hallucinogenic compounds are increasingly used in human research. However, due to limited information about potential subjective side effects, the controlled medical use of these compounds has remained controversial. We therefore analysed acute, short- and long-term subjective effects of psilocybin in healthy humans by pooling raw data from eight double-blind placebo-controlled experimental studies conducted between 1999 and 2008. The analysis included 110 healthy subjects who had received 1–4 oral doses of psilocybin (45–315 µg/kg body weight). Although psilocybin dose-dependently induced profound changes in mood, perception, thought and self-experience, most subjects described the experience as pleasurable, enriching and non-threatening. Acute adverse drug reactions, characterized by strong dysphoria and/or anxiety/panic, occurred only in the two highest dose conditions in a relatively small proportion of subjects. All acute adverse drug reactions were successfully managed by providing interpersonal support and did not need psychopharmacological intervention. Follow-up questionnaires indicated no subsequent drug abuse, persisting perception disorders, prolonged psychosis or other long-term impairment of functioning in any of our subjects. The results suggest that the administration of moderate doses of psilocybin to healthy, high-functioning and well-prepared subjects in the context of a carefully monitored research environment is associated with an acceptable level of risk.
In the evidence
This study is part of the evidence base for a synthesis in the library. Here is how each one recorded it.
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Moderate psilocybin doses were mostly described as pleasurable and non-threatening, but acute anxiety/panic occurred only at the two highest dose conditions in a small proportion of subjects and was managed with support.
Synthesized
Comparable studies
Other randomized controlled trials on psilocybin for anxiety, most cited first.