Effects of ibogaine on acute signs of morphine withdrawal in rats: independence from tremor.
Stanley D Glick, K Rossman, N C Rao, Isabelle M Maisonneuve, J N Carlson
Neuropharmacology May 1, 1992 DOI: 10.1016/0028-3908(92)90089-8 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Randomized controlled trial Peer reviewed |
|---|---|
| Population | Morphine-dependent rats |
| Intervention | Ibogaine |
| Dose | 20, 40 or 80 mg/kg |
| Duration | 5-day morphine administration; ibogaine given 30 min or 4 hr before naltrexone challenge; withdrawal signs counted for 2 hr after naltrexone |
| Topics | Ibogaine Addiction |
| Citations | 121 |
| Key findings | Ibogaine at 40 and 80 mg/kg significantly reduced four signs of naltrexone-precipitated withdrawal in morphine-dependent rats, even when tremors were absent. |
Abstract
Because of the claim that ibogaine suppresses the symptoms of "narcotic withdrawal" in humans, the effect of ibogaine on naltrexone-precipitated withdrawal signs in morphine-dependent rats was assessed. Morphine was administered subcutaneously through implanted silicone reservoirs for 5 days. Ibogaine (20, 40 or 80 mg/kg, i.p.) or saline was administered 30 min prior to challenge with naltrexone (1 mg/kg, i.p.) and withdrawal signs were counted for the following 2 hr. Ibogaine (40 and 80 mg/kg) significantly reduced the occurrence of four signs (wet-dog shakes, grooming, teeth chattering and diarrhea) during naltrexone-precipitated withdrawal; three other signs (weight loss, burying and flinching) were unaffected. Ibogaine induces head and body tremors lasting for 2-3 hr and the tremors might have interfered with the expression of opioid withdrawal. To examine this issue, another experiment was conducted in which ibogaine (40 mg/kg) or saline was administered 4 hr prior to challenge with naltrexone. Although there was a complete absence of tremors, ibogaine still significantly reduced the occurrence of the same four signs of withdrawal.
In the evidence
This study is part of the evidence base for a synthesis in the library. Here is how each one recorded it.
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Ibogaine at 40 and 80 mg/kg significantly reduced four signs of naltrexone-precipitated withdrawal in morphine-dependent rats, including when tremors were absent.
Synthesized
Comparable studies
Other preclinical and animal studies on ibogaine for addiction, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Glial Cell Line-Derived Neurotrophic Factor Mediates the Desirable Actions of the Anti-Addiction Drug Ibogaine against Alcohol Consumption Rats | 2005 | Experimental study | |
| Autoregulation of glial cell line-derived neurotrophic factor expression: implications for the long-lasting actions of the anti-addiction drug, Ibogaine. Dopaminergic-like SHSY5Y cell line | 2006 | In vitro cell culture study | |
| A dose-response study of ibogaine-induced neuropathology in the rat cerebellum. Rats | 2000 | Dose-response study | n = 30 |
| Oral noribogaine shows high brain uptake and anti-withdrawal effects not associated with place preference in rodents. Mice and rats | 2016 | Experimental study with three experiments | |
| Noribogaine reduces nicotine self-administration in rats. Adult male Sprague-Dawley rats | 2015 | Within-subject design with a Latin square test schedule |