Ibogaine selectively inhibits nicotinic receptor-mediated catecholamine release.
A S Schneider, J E Nagel, S J Mah
European Journal of Pharmacology December 19, 1996 DOI: 10.1016/s0014-2999(96)00815-1 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | In vitro experimental study Peer reviewed |
|---|---|
| Population | Cultured chromaffin cells |
| Intervention | Ibogaine |
| Dose | 1-10 µM, 100 µM |
| Topics | Ibogaine |
| Citations | 20 |
| Key findings | Low concentrations of ibogaine selectively inhibit nicotinic receptor-mediated catecholamine release, indicating action at the nicotinic acetylcholine receptor ion channel. |
Abstract
The effects of ibogaine, a putative anti-addictive drug, on stimulated catecholamine release were examined in cultured chromaffin cells to clarify its mechanism(s) of action. Low concentrations of ibogaine (1-10 microM) had a selective inhibitory action on nicotinic receptor-mediated catecholamine release, while higher concentrations (100 microM) inhibited additional modes of stimulated catecholamine release. These results suggest a selective inhibitory action of ibogaine at the nicotinic acetylcholine receptor, possibly at the receptor ion channel site.