Ibogaine affects brain energy metabolism.
Roman Paškulin, Polona Jamnik, Marko Živin, Peter Raspor, Borut Strukelj
European Journal of Pharmacology December 15, 2006 DOI: 10.1016/j.ejphar.2006.09.008 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal experimental study Peer reviewed |
|---|---|
| Population | Rat brains |
| Intervention | Ibogaine |
| Dose | 20 mg/kg body weight i.p. |
| Duration | 24 and 72 hours |
| Topics | Addiction Ibogaine |
| Keywords | Addiction treatment Addiction recovery Substance abuse treatment Drug rehabilitation Anti-addiction therapy Detoxification Relapse prevention Detoxify Reverse tolerance Neurobiology Brain health Brain function Neural mechanisms Brain metabolism Enzymes Cellular changes Energy metabolism Cellular energy Bioenergetics Mitochondrial function Atp production Cellular respiration Metabolic pathways Energy production |
| Citations | 24 |
| Key findings | Ibogaine treatment induced enzymes of glycolysis and the TCA cycle in rat brains, suggesting its anti-addiction effect may be mediated by increased energy metabolism. |
Abstract
Ibogaine is an indole alkaloid present in the root of the plant Tabernanthe iboga. It is known to attenuate abstinence syndrome in animal models of drug addiction. Since the anti-addiction effect lasts longer than the presence of ibogaine in the body, some profound metabolic changes are expected. The aim of this study was to investigate the effect of ibogaine on protein expression in rat brains. Rats were treated with ibogaine at 20 mg/kg body weight i.p. and subsequently examined at 24 and 72 h. Proteins were extracted from whole brain and separated by two-dimensional (2-D) electrophoresis. Individual proteins were identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS). Enzymes of glycolysis and tricarboxylic acid (TCA) cycle namely glyceraldehyde-3-phosphate dehydrogenase, aldolase A, pyruvate kinase and malate dehydrogenase were induced. The results suggest that the remedial effect of ibogaine could be mediated by the change in energy availability. Since energy dissipating detoxification and reversion of tolerance to different drugs of abuse requires underlying functional and structural changes in the cell, higher metabolic turnover would be favourable. Understanding the pharmacodynamics of anti-addiction drugs highlights the subcellular aspects of addiction diseases, in addition to neurological and psychological perspectives.
Comparable studies
Other preclinical and animal studies on ibogaine for addiction, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Glial Cell Line-Derived Neurotrophic Factor Mediates the Desirable Actions of the Anti-Addiction Drug Ibogaine against Alcohol Consumption Rats | 2005 | Experimental study | |
| Effects of ibogaine on acute signs of morphine withdrawal in rats: independence from tremor. Morphine-dependent rats | 1992 | Randomized controlled trial | |
| Autoregulation of glial cell line-derived neurotrophic factor expression: implications for the long-lasting actions of the anti-addiction drug, Ibogaine. Dopaminergic-like SHSY5Y cell line | 2006 | In vitro cell culture study | |
| A dose-response study of ibogaine-induced neuropathology in the rat cerebellum. Rats | 2000 | Dose-response study | n = 30 |
| Oral noribogaine shows high brain uptake and anti-withdrawal effects not associated with place preference in rodents. Mice and rats | 2016 | Experimental study with three experiments |
Citations in the library
Cited by 12
- Ibogaine, an anti-addictive drug: pharmacology and time to go further in development. A narrative review. Human & Experimental Toxicology March 1, 2008
- DARK Classics in Chemical Neuroscience: Ibogaine ACS Chemical Neuroscience September 14, 2018
- Ibogaine as a treatment for substance misuse: Potential benefits and practical dangers. Progress in Brain Research 2018
- The Iboga Alkaloids. Progress in the chemistry of organic natural products 2017
- Metabolic plasticity and the energy economizing effect of ibogaine, the principal alkaloid of Tabernanthe iboga. Journal of Ethnopharmacology August 30, 2012
and 7 more in the library
Cites 15
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- Inhibitory effects of ibogaine on cocaine self-administration in rats. European Journal of Pharmacology September 14, 1993
- Attenuation of alcohol intake by ibogaine in three strains of alcohol-preferring rats. Pharmacology, biochemistry, and behavior November 1, 1995
- Antagonism of alpha 3 beta 4 nicotinic receptors as a strategy to reduce opioid and stimulant self-administration. European Journal of Pharmacology March 1, 2002
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and 10 more in the library