Ketamine and Other NMDA Antagonists: Early Clinical Trials and Possible Mechanisms in Depression
American Journal of Psychiatry October 1, 2015 D. Jeffrey Newport, Linda L. Carpenter, William M. Mcdonald et al. 594 citations
OBJECTIVE: The authors conducted a systematic review and meta-analysis of ketamine and other N-methyl-d-aspartate (NMDA) receptor antagonists in the treatment of major depression. METHOD: Searches of MEDLINE, PsycINFO, and other databases were conducted for placebo-controlled, double-blind, randomized clinical trials of NMDA antagonists in the treatment of depression. Primary outcomes were...