Enhancing plasticity to treat depression and other central nervous system diseases using event-driven pharmacology.
Journal of psychopharmacology (Oxford, England) July 13, 2026 Todd D Gould, Sanjay J. Mathew, Maurizio Fava et al.
The occupancy-driven pharmacology model in psychopharmacology has guided drug discovery and development for decades, whereby the goal is stable receptor occupancy over an extended period with a direct relationship of drug exposure to pharmacodynamic and therapeutic response. Event-driven pharmacology (EDP) is a concept where the acute pharmacodynamic actions of a plastogen, a transient binding...