American Journal of Psychiatry
March 17, 2021
R. Mcintyre, J. Rosenblat, C. Nemeroff et al.
694 citations
Ketamine and esketamine are the first non-monoamine-based antidepressants with rapid-onset efficacy for adults with treatment-resistant depression, offering hope to those who do not recover fully with standard antidepressants. However, concerns remain about their safety, tolerability, and appropriate placement in treatment algorithms. An international group of mood disorder experts synthesizes evidence on efficacy, safety, and tolerability, and provides guidance for clinical implementation, including practice parameters at point of care. Areas of consensus and future research directions are discussed.
British medical journal
February 2, 2022
M. Abbar, C. Demattei, W. El-Hage et al.
172 citations
Two intravenous infusions of ketamine (0.5 mg/kg) given 24 hours apart, added to usual treatment, led to full remission of suicidal ideas by day 3 in 63.0% of hospitalized patients with suicidal ideation, compared to 31.6% with placebo. The benefit was strongest in patients with bipolar disorder (odds ratio 14.1), not significant in those with depressive disorder (odds ratio 1.3), and intermediate for other disorders (odds ratio 3.7). At six weeks, remission remained high in the ketamine group (69.5% vs 56.3%) but was no longer statistically significant. Side effects were limited, with no manic or psychotic symptoms observed. An analgesic effect on mental pain may explain the anti-suicidal action.
Eur Psychiatry
June 16, 2026
A.H. Young, L. Bartova, N. Cardoner et al.
No Summary
Journal of Affective Disorders
July 21, 2020
A. Docteur, C. Mirabel-Sarron, Héline Kaya Lefèvre et al.
Mindfulness-based cognitive therapy (MBCT) reduces depressive symptoms, dysfunctional attitudes, and overgeneral autobiographical memories while increasing specific memories in people with bipolar I disorder. Patients who received MBCT showed significantly fewer depressive symptoms and less overgeneral memory compared to those on a waiting list. Baseline general autobiographical memory and omissions predicted lower anxiety and dysfunctional attitudes improvement after therapy, but memory improvement did not explain MBCT's effect on depression or dysfunctional attitudes. The findings suggest that MBCT reduces cognitive reactivity and memory impairment in bipolar disorder, and that autobiographical memory training before MBCT may influence its efficacy, but memory improvement and clinical symptom improvement are unrelated.
European Psychiatry
November 1, 2015
L. Sala, C. Vindreau, S. Sweerts et al.
Mindfulness-based programs adapted from MBSR and MBCT, which focus on self-regulation and acceptance of unpleasant emotions and sensations, offer a promising approach for eating disorders where control and avoidance are prominent. These programs target obsessive aspects (e.g., rumination) and compulsive aspects (e.g., loss-of-control eating) associated with these disorders. At the CMME, Sainte-Anne Hospital, an eight-session 'MBCT Bulimia' protocol was developed, modifying cognitive tools and meditation duration for patients with eating disorders. The study involved twenty-four subjects from the day hospital and aimed to evaluate the program's impact on bulimia and binge eating disorder. Preliminary results are presented, along with plans for further clinical research.