Biased agonism in psychopharmacology: an opportunity to improve efficacy and safety of treatments.
CNS Spectrums August 12, 2025 Gia Han Le, Sabrina Wong, Stavroula Bargiota et al. 3 citations
G protein-coupled receptors (GPCRs) are involved in many physiological and pathophysiological processes. Conventional pharmacological models categorize the typology of pharmacologic ligands as agonists or antagonists. Biased agonism is a relatively newer pharmacodynamic characteristic that has potential to optimize therapeutic efficacy while minimizing adverse effects in psychiatric and...