Psychedelics Relax Priors and Reshape Orbitofrontal Dynamics
bioRxiv Preprint Server September 18, 2025 C. Delgado-Sallent, S. A. Ahmed, A. Khawaja-Lopez et al. preprint
Psychedelics such as psilocybin and ketamine are gaining attention as rapid-acting treatments for psychiatric disorders, yet the mechanisms by which they alter cognition remain unclear. A key hypothesis—the REBUS model—proposes that psychedelics relax high-level priors, allowing bottom-up sensory information to exert greater influence over perception and behavior. Here, we test this model in...