Lateral Septal Circuits Govern Schizophrenia-Like Effects of Ketamine on Social Behavior
bioRxiv Preprint Server August 8, 2023 Ruixiang Wang, Zeru Peterson, Nagalakshmi Balasubramanian et al. 1 citation preprint
Schizophrenia is marked by poor social functioning that can have a severe impact on quality of life and independence, but the underlying neural circuity is not well understood. Here we used a translational model of subanesthetic ketamine in mice to delineate neural pathways in the brain linked to social deficits in schizophrenia. Mice treated with chronic ketamine (30 mg/kg/day for 10 days)...