Is the antidepressant effect of ketamine separate from its psychotomimetic effect? A review of rodent models.
Neuropharmacology November 1, 2024 M C Acero-Castillo, M B M Correia, F V Caixeta et al. 7 citations
Ketamine is an NMDA (N-methyl-d-aspartate) glutamate receptor antagonist, which has a myriad of dose-dependent pharmacological and behavioral effects, including anesthetic, sedative, amnestic, analgesic, and anti-inflammatory properties. Intriguingly, ketamine at subanesthetic doses displays a relevant profile both in mimicking symptoms of schizophrenia and also as the first fast-acting...