Psychedelic-like Properties of Quipazine and Its Structural Analogues in Mice
ACS Chemical Neuroscience January 5, 2021 M. de la Fuente Revenga, Urjita H. Shah, Nima Nassehi et al.
Known classic psychedelic serotonin 2A receptor (5-HT2AR) agonists retain a tryptamine or phenethylamine at their structural core. However, activation of the 5-HT2AR can be elicited by drugs lacking these fundamental scaffolds. Such is the case of the N-substituted piperazine quipazine. Here, we show that quipazine bound to and activated 5-HT2AR as measured by [3H]ketanserin binding...