Experimenters’ sex modulates mouse behaviors and neural responses to ketamine via corticotropin releasing factor
Nature Neuroscience August 30, 2022 P. Georgiou, P. Zanos, Ta-Chung M. Mou et al.
We show that the sex of human experimenters affects mouse behaviors and responses following administration of the rapid-acting antidepressant ketamine and its bioactive metabolite (2R,6R)-hydroxynorketamine. Mice showed aversion to the scent of male experimenters, preference for the scent of female experimenters and increased stress susceptibility when handled by male experimenters. This...