The synergistic mechanism of action of Dajianzhong decoction in conjunction with ketamine in the treatment of depression.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie September 2023 Chan Li, Jiping Zhang, Hanhe Liu et al.
Depression is a multifactorial syndrome with a variety of underlying pathological mechanisms. While ketamine, an N-methyl-D-aspartate receptor (NMDAR) antagonist, exhibits a rapid antidepressant action in the central never system (CNS), the potential addiction and psychotomimetic adverse effects of ketamine limit its chronic use in clinical practice. Therefore, it is necessary to discover an...