Ketamine strengthens synaptic inputs to the dorsal raphé to boost serotonergic activity: pivotal for rapid antidepressant-like effects
Soukaina Es-Safi, Céline Bourcier-Lucas, Erika Abrial et al. preprint
ABSTRACT Ketamine at subanaesthetic dose is known as a fast-acting antidepressant (AD), able to facilitate synaptic plasticity in the medial prefrontal cortex (mPFC) or the hippocampus. However, its influence on the serotonergic (5-HT) system is more confusing as it loses its behavioral effects in 5-HT-depleted animals, but does not modify 5-HT neuron function. We hypothesized that this...