A Randomized Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Major Depression
Archives of General Psychiatry August 1, 2006 Carlos A. Zarate, Jaskaran Singh, Paul J. Carlson et al. 3,762 citations
CONTEXT: Existing therapies for major depression have a lag of onset of action of several weeks, resulting in considerable morbidity. Exploring pharmacological strategies that have rapid onset of antidepressant effects within a few days and that are sustained would have an enormous impact on patient care. Converging lines of evidence suggest the role of the glutamatergic system in the...