Mesolimbic dopaminergic decline after cannabinoid withdrawal.
Proceedings of the National Academy of Sciences of the United States of America August 18, 1998 M Diana, M Melis, A L Muntoni et al.
The mesolimbic dopamine system has recently been implicated in the long-term aversive consequences of withdrawal from major drugs of abuse. In the present study we sought to determine whether mesolimbic dopamine neurons are involved in the neurobiologic mechanisms underlying withdrawal from chronic cannabinoid exposure. Rats were treated chronically with the major psychoactive ingredient of...