Characterization of MK-801-induced behavior as a putative rat model of psychosis.
Journal of Pharmacology and Experimental Therapeutics September 1, 1999 Peter Andiné, Nina Widermark, R. Axelsson et al.
The objective of this study was to characterize the behavior induced by the N-methyl-D-aspartate receptor antagonist MK-801 (dizocilpine maleate) in rats as a model of psychosis. The temporal profile, dose dependence, age, and sex differences of the behavior are described. A gas chromatographic method for the analysis of MK-801 in plasma and brain was developed. Female rats showed 4 to 10 times...