Neurotoxicity of Ecstasy metabolites in rat cortical neurons, and influence of hyperthermia.
The Journal of pharmacology and experimental therapeutics January 2006 João Paulo Capela, Andreas Meisel, Artur Reis Abreu et al.
3,4-Methylenedioxymethamphetamine (MDMA or "Ecstasy") is a widely abused, psychoactive recreational drug. There is growing evidence that the MDMA neurotoxic profile may be highly dependent on both its hepatic metabolism and body temperature. Metabolism of MDMA involves N-demethylation to 3,4-methylenedioxyamphetamine (MDA), which is also a drug of abuse. MDMA and MDA are O-demethylenated to...