A behavioral and molecular analysis of ketamine in zebrafish.
Synapse (New York, N.Y.) February 2011 Sherry M Zakhary, Diana Ayubcha, Farah Ansari et al.
Ketamine exerts powerful anesthetic, psychotic, and antidepressant effects in both healthy volunteers and clinically depressed patients. Although ketamine targets particular glutamate receptors, there is a dearth of evidence for additional, alternative molecular substrates for the behavioral actions of this N-methyl-D-aspartate (NMDA) receptor antagonist drug. Here, we provide behavioral and...