Ciliopathy interacts with neonatal anesthesia to cause non-apoptotic caspase-mediated motor deficits.
bioRxiv : the preprint server for biology November 27, 2024 Nemanja Sarić, Zeynep Atak, Courtni Foster Sade et al. preprint
Increasing evidence suggests that anesthesia may induce developmental neurotoxicity, yet the influence of genetic predispositions associated with congenital anomalies on this toxicity remains largely unknown. Children with congenital heart disease often exhibit mutations in cilia-related genes and ciliary dysfunction, requiring sedation for their catheter or surgical interventions during the...