The role of BDNF promoter VI in mediating protective effects of prophylactic (R,S)-ketamine.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology August 29, 2026 Briana K Chen, Brenna L Williams, Anna Darling et al.
Brain-derived neurotrophic factor (BDNF) exon VI promoter is implicated in mediating activity-induced synthesis of hippocampal BDNF. BDNF is implicated in (R,S)-ketamine's antidepressant effects, but its role in (R,S)-ketamine-mediated prophylaxis is unknown. Using BDNF-e6 mice, in which promoter VI-driven BDNF production is disrupted, we tested its necessity for (R,S)-ketamine's prophylactic...