Acute effects of cannabinoids on symptoms of obsessive-compulsive disorder: A human laboratory study.
Depression and Anxiety August 1, 2020 Reilly R Kayser, Margaret Haney, Marissa Raskin et al.
In adults with obsessive-compulsive disorder (OCD), smoked cannabis containing primarily THC or CBD had little acute effect on OCD symptoms and produced smaller reductions in anxiety than placebo. In a randomized, placebo-controlled, within-subjects laboratory study, 12 participants completed three sessions smoking placebo (0% THC/0% CBD), THC (7.0% THC/0.18% CBD), or CBD (0.4% THC/10.4% CBD). Self-reported OCD symptoms and anxiety decreased over time in all conditions, but OCD symptoms did not differ by cannabis varietal. State anxiety was significantly lower immediately after placebo than after either active cannabis. THC increased heart rate, blood pressure, and intoxication relative to placebo and CBD.