NMDA receptors antagonists alleviated the acute phase of traumatic brain injury.
Iranian journal of basic medical sciences 2025 Mehrdad Hajinejad, Ahmadreza Gharaeian Morshed, Abdolreza Narouiepour et al. 1 citation
Traumatic brain injury (TBI) is a significant cause of mortality and disability worldwide. TBI has been associated with factors such as oxidative stress, neuroinflammation, and apoptosis, which are believed to be mediated by the N-methyl-D-aspartate (NMDA)-type glutamate receptor. Two NMDA receptor antagonists, ketamine and memantine, have shown potential in mitigating the pathophysiological...