Neurobiological correlates of treatment-resistant depression: implications for pharmacotherapy
Neuropsychiatria i Neuropsychologia 2026 Joanna Kot, Ewa Ferensztajn-Rochowiak, Oryna Kaliuzhna et al.
Treatment-resistant depression (TRD) affects about 30% of patients with major depressive disorder and remains a major clinical challenge.The limited effectiveness of classical antidepressants suggests that the pathophysiology of TRD is complex and extends beyond the traditional monoamine hypothesis.The aim of this paper was to present current concepts of the neurobiological background of TRD...