S-ketamine exerts sex- and dose-dependent anti-compulsive-like effect as monotherapy or in augmentation to fluoxetine.
European Journal of Pharmacology November 1, 2022 Júlia Grigorini Mori Ayub, C. Tosta, Breno Lopes Macedo et al.
Female mice are less sensitive than male mice to the anti-compulsive-like effect of S-ketamine, both when used alone and as an adjuvant to fluoxetine. S-ketamine reduced compulsive-like behavior in female mice only at a dose of 30 mg/kg, whereas the effective dose in male mice is 10 mg/kg. Combining sub-effective doses of S-ketamine and fluoxetine reduced marble-burying behavior in both sexes, but male mice showed a better response. Variations in female sex hormones (estrogen and progesterone), inferred from the estrous cycle and ovariectomy, did not influence S-ketamine's effect.