Differential and region-specific activation of mitogen-activated protein kinases following chronic administration of phencyclidine in rat brain.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology March 1, 2001 S V Kyosseva, S M Owens, A D Elbein et al.
We have previously demonstrated elevation of the extracellular signal-regulated kinase (ERK) pathway in the cerebellum from patients with schizophrenia, an illness that may involve dysfunction of the N-methyl-D-aspartate (NMDA) receptor. Since the NMDA antagonist, phencyclidine (PCP), produces schizophrenic-like symptoms in humans, and abnormal behavior in animals, we examined the effects of...