Brain Research Bulletin Special Issue: Brain-body communication in health and diseases Brain-spleen axis in health and diseases: a review and future perspective.
Brain Research Bulletin February 1, 2022 Yan Wei, Tong Wang, Lei Liao et al.
The spleen, an important tissue for the immune system, acts as a filter for blood within the immune system. Accumulating evidence suggests that the spleen affects a number of brain functions in health and diseases via immune modulation. Systemic inflammation or chronic social defeat stress (CSDS) can cause splenomegaly in rodents. Interestingly, the new antidepressant arketamine could normalize...