Effects of N-Acetylaspartylglutamate (NAAG) Peptidase Inhibition on Release of Glutamate and Dopamine in Prefrontal Cortex and Nucleus Accumbens in Phencyclidine Model of Schizophrenia*
Journal of Biological Chemistry May 8, 2012 Daiying Zuo, T. Bzdȩga, R. Olszewski et al.
Background: Inhibitors of the enzyme that inactivates the peptide transmitter N-acetylaspartylglutamate reduce behaviors induced by PCP in animal models of schizophrenia. Results: NAAG peptidase inhibition reduces PCP-induced glutamate release in two brain areas implicated in this disorder. Conclusion: Peptidase-mediated inhibition of glutamate release is consistent with the glutamate model of...