Paula Kiuru

2 papers in the library · publishing 2019

Papers

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Ketamine-induced regulation of TrkB-GSK3β signaling is accompanied by slow EEG oscillations and sedation but is independent of hydroxynorketamine metabolites.

Neuropharmacology October 1, 2019 Samuel Kohtala, Wiebke Theilmann, Marko Rosenholm et al.

Subanesthetic rather than anesthetic doses are thought to bring the rapid antidepressant effects of the NMDAR (N-methyl-d-aspartate receptor) antagonist ketamine. Among molecular mechanisms, activation of BDNF receptor TrkB along with the inhibition of GSK3β (glycogen synthase kinase 3β) are considered as critical molecular level determinants for ketamine's antidepressant effects....

DOI: 10.1016/j.neuropharm.2019.107684 Full text Ketamine Anesthesia Antidepressant Sedation +2

Putative rapid-acting antidepressant nitrous oxide (“laughing gas”) evokes rebound emergence of slow EEG oscillations during which TrkB signaling is induced

Samuel Kohtala, Wiebke Theilmann, Marko Rosenholm et al. preprint

Abstract Electroconvulsive therapy (ECT) remains among the most efficient antidepressants but it seldom brings immediate remedy. However, a subanesthetic dose of NMDA-R (N-methyl-D-aspartate receptor) blocker ketamine ameliorates symptoms of depression already within hours. Glutamatergic excitability and regulation of TrkB neurotrophin receptor and GSK3β (glycogen synthase kinase 3β) signaling...

DOI: 10.1101/282954