Adolescent cannabinoid exposure delays development of prefrontal cortex perineuronal nets and inhibitory interneurons.
Neuroscience March 23, 2026 Eliza Jacobs-Brichford, Rachel M. Donka, Amy W. Lasek et al.
Maturation of inhibitory signaling during critical period development depends on neural activity driven by experience. Parvalbumin positive (PV+) interneurons, the dominant type of inhibitory interneuron in prefrontal cortex (PFC), undergo critical period development during adolescence. Their maturation is supported by perineuronal nets (PNNs), lattice-like extracellular matrix structures that...